Borane → Fluoxetine

HRID 377463Notes

Reaction equation

HRID 377463 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:24]=[CH:23][C:6]([O:7][CH:8]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:9][CH2:10][NH:11][C:12](OCC)=O)=[CH:5][CH:4]=1.B>>[CH3:12][NH:11][CH2:10][CH2:9][CH:8]([C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)[O:7][C:6]1[CH:23]=[CH:24][C:3]([C:2]([F:26])([F:25])[F:1])=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 6331BoraneHCID 70077779HCID 70077779, compound

Product 1

HCID 3386Fluoxetine

Procedure

reducing said N-[3-[4-(trifluoromethyl)phenoxy]-3-phenylpropyl)urethane with borane or a metal hydride to provide N-methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine.

Sources & evidence

ORD record
ord-3812c1bab34d4090b0e6db0cec969648
Source dataset
uspto-grants-2000_02
Patent number
US06025517

Reaction notes

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