HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → trans-3,3-Diethoxy-1,2-cyclobutanedicarboxylic acid, diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,1-Diethoxyethene | HCID 137673 | — |
| Reactant | Diethyl fumarate | HCID 638144 | — |
| Reactant | Diisobutyl aluminium chloride | HCID 16686353 | — |
| Product | trans-3,3-Diethoxy-1,2-cyclobutanedicarboxylic acid, diethyl ester | HCID 14378472 | — |
Reaction Steps
By the method of Example 1, diethyl fumarate was reacted at -40° C. with 2 equivalents of ketene diethyl acetal in the presence of 0.2 equivalents of ethyldiisopropylamine and 2 equivalents of diisobutylaluminium chloride. 1H NMR analysis of the reaction mixture showed that the yield was quantitative.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06025519 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-f3657800254e48c1868601930e701594 |
| Source note | uspto-grants-2000_02 |