HuagongsheHuagongshe Chemistry Print Report · For research reference only
Betahistine → 9-Ethyl-4-[(2-(pyridin-2-yl)ethyl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Betahistine | HCID 2366 | — |
| Reactant | 4,6-Dichloro-5-nitropyrimidine | HCID 20312 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 2-Ethylimidazole | HCID 66130 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Product | 9-Ethyl-4-[(2-(pyridin-2-yl)ethyl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one | HCID 19358859 | — |
Reaction Steps
Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with 2-(2-(methylamino)ethyl)pyridine followed by reaction with 2-ethylimidazole, reduction with tin (II) chloride and cyclization with carbonyidiimidazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06025489 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-83047f3e8901494e9a721f7f8a623fa2 |
| Source note | uspto-grants-2000_02 |