Methanol → 9-Ethyl-4-[(2-hydroxyethyl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one

HRID 377516Notes

Reaction equation

HRID 377516 reaction equation

[CH2:1]([C:3]1[N:15]2[C:6]([C:7](=[O:28])[NH:8][C:9]3[C:10]([N:16]([CH2:18][CH2:19][O:20]CC4C=CC=CC=4)[CH3:17])=[N:11][CH:12]=[N:13][C:14]=32)=[CH:5][N:4]=1)[CH3:2].CO.[OH-].[Na+]>[Pd]>[CH2:1]([C:3]1[N:15]2[C:6]([C:7](=[O:28])[NH:8][C:9]3[C:10]([N:16]([CH2:18][CH2:19][OH:20])[CH3:17])=[N:11][CH:12]=[N:13][C:14]=32)=[CH:5][N:4]=1)[CH3:2]

Participants

5

Reactant 3

HCID 887Methanol

HCID 14798Sodium Hydroxide

HCID 99517039-Ethyl-4-[(2-(phenylmethoxy)ethyl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one

Product 1

HCID 193588759-Ethyl-4-[(2-hydroxyethyl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared by hydrogenation of the product of Example 24 with palladium on carbon in methanol containing 1.1 eq. NaOH at 50 psi for 8 hours.

Sources & evidence

ORD record: ord-91dc5346d9c04465818bb41fb9cf9b3f
Source dataset: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06025489

Reaction notes

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