HCID 15790817, compound → HCID 15790818, compound

HRID 377538Notes

Reaction equation

HRID 377538 reaction equation
[Cl:1][C:2]1[C:3]([N:12]2[C:16]([CH2:17][OH:18])=[C:15]([C:19]#[N:20])[CH:14]=[N:13]2)=[N:4][N:5]([CH3:11])[C:6]=1[O:7][CH:8]([F:10])[F:9].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>ClCCl>[Cl:1][C:2]1[C:3]([N:12]2[C:16]([CH:17]=[O:18])=[C:15]([C:19]#[N:20])[CH:14]=[N:13]2)=[N:4][N:5]([CH3:11])[C:6]=1[O:7][CH:8]([F:10])[F:9]

Participants

4

Reactant 2

HCID 15790817HCID 15790817, compoundHCID 178418287HCID 178418287, compound

Product 1

HCID 15790818HCID 15790818, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

29 g (9.6 mmol) 1-(4-chlor-5-difluormethoxy-1-methyl-3-pyrazolyl)-5-hydroxymethyl-4-pyrazol-carbonitrile is added to 30 ml dichloromethane and 15.2 g pyridinium chlorochromate on aluminium oxide is then added. Stirring continues for 1 hour at room temperature and then the reaction mixture is vacuum filtered through Celite and purified by means of column chromatography using hexane/ethyl acetate.

Workup

  1. additionis then added
  2. filtrationfiltered through Celite
  3. custompurified by means of column chromatography

Sources & evidence

ORD record
ord-4c4fe35db677446eb37e19d4141d1199
Source dataset
uspto-grants-2000_02
Patent number
US06028034

Reaction notes

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