m-Chloroperbenzoic acid → HCID 19354588, compound

Participants

Reaction Conditions

Reaction Steps

m-Chloroperoxybenzoic acid (75% pure, 0.54 g) was added to a stirred solution of N-(2,5-difluorophenyl)-2-(2,3-dihydro-6-methylthiomethyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methylpropanamide (compound 1, 100 g) in dichloromethane at -20° C. The mixture was stirred at -20° C. for 1 hour, diluted with dichloromethane, washed with 1M sodium carbonate, dried (magnesium sulphate) and solvent evaporated under reduced pressure. The residue was triturated with diethyl ether to give N-(2,5-difluorophenyl)-2-(2,3-dihydro-6-methylsulphinylmethyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methylpropanamide (compound 5, 0.51 g) as a white solid, m.p. 124-128° C.

Provenance & Evidence