Potassium Carbonate → HCID 19354644, compound

Participants

Reaction Steps

A solution of potassium carbonate (0.33 g) in water was added portionwise to a stirred solution of N-(3-trifluoromethylphenyl)-2-(6-acetoxymethyl-2,3-dihydro-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methylpropanamide (0.8 g) in methanol. Stirring was continued for 4 hours at room temperature, the mixture evaporated and the residue dissolved in a mixture of ether and water. The organic layer was dried (magnesium sulphate), evaporated and the residue purified by dry column chromatography eluting with ether to give N-(3-trifluoromethylphenyl)-2-(2,3-dihydro-6-hydroxymethyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methylpropanamide (compound 102, 0.31 g) as a gum, NMR (CDCl3)δ 1.7(s,6H), 4.1(d,2H), 5.3(s,2H), 7.1-7.3(m,7H), 7.55(m,1H), 7.75(m,1H), 8.3(s,1H).

Provenance & Evidence