HCID 19354581, compound → HCID 19354605, compound

Participants

Reaction Steps

A solution of N-(2,5-difluorophenyl)-2-(2,3-dihydro-6-hydroxymethyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methylpropanamide (1.0 g) in dichloromethane was added to a stirred mixture of pyridinium chlorochromate (0.8 g) and powdered 4A molecular sieve (1.6 g) in dichloromethene. After 2 hours the mixture was purified directly by dry column chromatography on silica gel, eluting with dichloromethane to give N-(2,5-difluorophenyl)-2-(2,3-dihydro-6-formyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methylpropanamide (compound 129, 0.83 g) as a pale green solid, m.p. 76-77.5° C.

Provenance & Evidence