Methanol → HCID 10710154, compound

Participants

Reaction Steps

A guanidine solution prepared--as described in Example 3--from 547 mg of sodium, 12 ml of methanol and 2.5 g of guanidine hydrochloride is treated with 1.2 g of methyl 2,3-dihydro-5-methyl-3-methylene-1-benzothiophene-6-carboxylate-1,1-dioxide [prepared by cyclization of methyl 4-acetyl-2-methyl-5-methylsulfonylbenzoate and subsequent dehydration] and the mixture is boiled for 1 hour, then stirred at room temperature for a further hour and worked up in the customary manner. N-Diaminomethylene-2,3-dihydro-3-methoxy-3,5-dimethyl-1-benzothiophene-6-carboxamide-1,1-dioxide is obtained. Treatment with methanesulfonic acid in methanol gives the corresponding methanesulfonate, m.p. 214-215°.

Provenance & Evidence