Toluene → HCID 53778754, compound

HRID 377605Notes

Reaction equation

HRID 377605 reaction equation
[C:1]1([CH2:7][C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:12])=O.[C:14]1([CH3:20])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[Cl:12][CH:20]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:3]1[CH:2]=[C:1]([CH2:7][C:8]#[N:9])[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 1140TolueneHCID 8794PhenylacetonitrileHCID 24386Thionyl Chloride

Product 1

HCID 53778754HCID 53778754, compound

Procedure

9 g of 3-hydroxyphenylmethyl)phenylacetonitrile are dissolved in 150 ml of toluene and treated with stirring with 5.8 ml (80 mmol) of thionyl chloride. The reaction mixture is heated to reflux temperature and stirred for one hour. In the course of this, approximately 50 ml of toluene are removed in a water separator. The solvent is removed and 3-(chlorophenyl-methyl)phenylacetonitrile is obtained.

Workup

  1. additiontreated
  2. temperatureThe reaction mixture is heated
  3. temperatureto reflux temperature
  4. customIn the course of this, approximately 50 ml of toluene are removed in a water separator
  5. customThe solvent is removed

Sources & evidence

ORD record
ord-715a8484b6f945f58156c48cdbcf18eb
Source dataset
uspto-grants-2000_02
Patent number
US06028080

Reaction notes

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