反应详情

温度

100 °C

25.7 g of ethyl 4-bromomethylphenylacetate and 28 g of hexamethylenetetramine are dissolved in 200 ml of 20% acetic acid, heated to 100° C. with stirring and stirred for four hours. The reaction solution is allowed to cool and sufficient sodium carbonate is added until a saturated solution is obtained. This solution is extracted with ether, dried and the ether is then removed. The residue is purified by chromatography (silica gel/methyl t-butyl ether/ether 1:1).

1. stirringstirred for four hours
2. temperatureto cool
3. customis obtained
4. extractionThis solution is extracted with ether
5. customdried
6. customthe ether is then removed
7. customThe residue is purified by chromatography (silica gel/methyl t-butyl ether/ether 1:1)