Carbon tetrabromide → HCID 19356218, compound

Participants

Reaction Steps

Dissolved in 30 ml of tetrahydrofuran were 0.352 g (1 mmol) of ethyl 4-(2-hydroxyethylamino)-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylate, 0.67 g (2 mmol) of carbon tetrabromide and 0.531 g (2 mmol) of triphenylphosphine, followed by a reaction at room temperature for 5 hours. The insoluble matter was filtered off, and the organic layer was concentrated under reduced pressure. The resulting residue was purified by chromatography on a silica gel column and then recrystallized from ethyl acetate/isopropyl ether, whereby 0.31 g of ethyl 4-(2-bromoethylamino)-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylate was obtained (yield: 74.7%).

Provenance & Evidence