O-Toluidine → HCID 19356228, compound

Participants

Reaction Steps

A mixture consisting of 1.0 g (3.05 mmol) of ethyl 4-chloro-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylate and 6.5 g (60.7 mmol) of o-toluidine was reacted at 100° C. for 5 hours. After the reaction, chloroform was added, and the resultant mixture was washed with a 5% aqueous solution of potassium hydrogensulfate and was then dried. The solvent was distilled off under reduced pressure, and the residue so obtained was purified by chromatography on a silica gel and was then recrystallized from ethanol/water, whereby 0.844 g of ethyl 4-(2-methylphenylamino)-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylate (Compound No. 33) was obtained (yield: 69.5%).

Provenance & Evidence