HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromomethyl acetate → 5,6-Dichloro-1-[6-[1-(acetyloxy)methyl-2-methylpyridinium-3-yl-oxy]pyridin-3-ylcarbamoyl]indoline chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromomethyl acetate | HCID 68536 | — |
| Reactant | Sodium Tetraphenylborate | HCID 2723787 | — |
| Reactant | 5,6-Dichloro-1-[6-(2-methylpyridin-3-yloxy)pyridin-3-ylcarbamoyl]indoline | HCID 19356259 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5,6-Dichloro-1-[6-[1-(acetyloxy)methyl-2-methylpyridinium-3-yl-oxy]pyridin-3-ylcarbamoyl]indoline chloride | HCID 19356266 | 80% |
Reaction Steps
5,6-Dichloro-1-[6-(2-methylpyridin-3-yloxy)pyridin-3-ylcarbamoyl]indoline (0.25 g, 0.6 mmol) was treated with bromomethyl acetate and sodium tetraphenylboron at reflux in acetonitrile (15 ml) for 10 h according to the procedure described in Example 1 to give the title compound (E3) (0.26 g, 80%) m.p. 125-135° C. which contained approximately 15% starting material as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06028085 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-346548e1d75c495b94bdc8b45954bf80 |
| Source note | uspto-grants-2000_02 |