HCID 54219844, compound → HCID 22456975, compound

Participants

Reaction Conditions

Reaction Steps

3-Fluoro-4-methoxy-α-methylcinnamic acid (49.5 g, 0.236 mol) in methanol (800 ml) at 20° C. is hydrogenated at 43 psi until the theoretical uptake of hydrogen has occurred (24 min. with 1.5 g platinum oxide catalyst). The solution is filtered, and is evaporated with warming to 60° C. to give 3-fluoro-4-methoxy-α-methyl dihydrocinnamic acid, Rf 0.5 on silica-gel G with methylene chloride-methanol (9:1).

Provenance & Evidence