HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → (Z)-5-Fluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-3-indenylacetyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | (Z)-5-fluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-3-indenylacetic acid | HCID 9864863 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (Z)-5-Fluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-3-indenylacetyl chloride | HCID 86755162 | — |
Reaction Steps
(Z)-5-fluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-3-indenylacetic acid (70 mmol) in THF (500 ml) is allowed to react with oxalylchloride (2 M in CH2Cl2 ; 35 ml) under reflux conditions (24 hours). The solvent is evaporated to yield the title compound, which is used as such in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06028116 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-8ad4c4e37c21415d8af68300fa6aee3d |
| Source note | uspto-grants-2000_02 |