Ammonia → N-(2,2-Dimethoxyethyl)thiourea

HRID 377767Notes

Reaction equation

HRID 377767 reaction equation
[NH3:1].[CH3:2][O:3][CH:4]([O:9][CH3:10])[CH2:5][N:6]=[C:7]=[S:8]>CO>[CH3:2][O:3][CH:4]([O:9][CH3:10])[CH2:5][NH:6][C:7]([NH2:1])=[S:8]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 144710Isothiocyanatoacetaldehyde dimethyl acetal

Product 1

HCID 19356278N-(2,2-Dimethoxyethyl)thiourea

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methanol (200 mL) was saturated with ammonia and stirred with isothiocyanatoacetaldehyde dimethyl acetal (5.0 g) for 2 h. The mixture was concentrated and the residue was chromatographed (silica gel, 5% methanol/dichloromethane) to give the title compound.

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue was chromatographed (silica gel, 5% methanol/dichloromethane)

Sources & evidence

ORD record
ord-a36e44436710468abec7fc2fdab510d1
Source dataset
uspto-grants-2000_02
Patent number
US06028087

Reaction notes

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