HCID 54018255, compound → HCID 53762712, compound
Reaction equation
CC(N1CCN(CC(O)=O)CCN(C(C)C(O)=O)CCN(C(C)C(O)=O)CC1)C(O)=O.C1(C[O:39][CH2:40][CH:41]([N:45]2[CH2:56][CH2:55][N:54]([CH2:57][C:58]([OH:60])=[O:59])[CH2:53][CH2:52][N:51]([CH:61]([CH2:65][O:66]CC3C=CC=CC=3)[C:62]([OH:64])=[O:63])[CH2:50][CH2:49][N:48]([CH:74]([CH2:78][O:79]CC3C=CC=CC=3)[C:75]([OH:77])=[O:76])[CH2:47][CH2:46]2)[C:42]([OH:44])=[O:43])C=CC=CC=1>>[OH:66][CH2:65][CH:61]([N:51]1[CH2:52][CH2:53][N:54]([CH2:57][C:58]([OH:60])=[O:59])[CH2:55][CH2:56][N:45]([CH:41]([CH2:40][OH:39])[C:42]([OH:44])=[O:43])[CH2:46][CH2:47][N:48]([CH:74]([CH2:78][OH:79])[C:75]([OH:77])=[O:76])[CH2:49][CH2:50]1)[C:62]([OH:64])=[O:63]Participants
3
Procedure
By way of example of the huge potentialities given by this synthetic route, the synthesis of the novel compound, α,α',α"-tris(methyl)-1,4,7,10-tetraazacyclo-dodecane-1,4,7,10-tetraacetic acid, is reported in Experimental section: ##STR12## as well as that of α,α',α"-tris [(phenylmethoxy)methyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid ##STR13## which, by catalytic hydrogenation, as described in example 6 of the cited Patent, yields α,α',α"-tris(hydroxymethyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid. ##STR14##
Sources & evidence
- ORD record
- ord-17665e735f0d4cffaed3b3735b788d15
- Source dataset
- uspto-grants-2000_02
- Patent number
- US06028194
Reaction notes
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