Phenyl N-(5-ethyl-2-methoxy-6-methylpyridin-3-yl)carbamate → 1-[(5-Ethyl-6-methyl-2-methoxypyridin-3-yl)aminocarbonyl]-4-(2-isopropenylphenyl)piperazine

HRID 377822Notes

Reaction equation

HRID 377822 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([NH:12][C:13](=[O:21])OC2C=CC=CC=2)[C:6]([O:10][CH3:11])=[N:7][C:8]=1[CH3:9])[CH3:2].[C:22]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1)([CH3:24])=[CH2:23]>>[CH2:1]([C:3]1[CH:4]=[C:5]([NH:12][C:13]([N:34]2[CH2:35][CH2:36][N:31]([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[C:22]([CH3:24])=[CH2:23])[CH2:32][CH2:33]2)=[O:21])[C:6]([O:10][CH3:11])=[N:7][C:8]=1[CH3:9])[CH3:2]

Participants

3

Reactant 2

HCID 19357010Phenyl N-(5-ethyl-2-methoxy-6-methylpyridin-3-yl)carbamateHCID 19357124HCID 19357124, compound

Product 1

HCID 193570141-[(5-Ethyl-6-methyl-2-methoxypyridin-3-yl)aminocarbonyl]-4-(2-isopropenylphenyl)piperazineYield 51%

Procedure

Phenyl N-(5-ethyl-6-methyl-2-methoxypyridin-3-yl)carbamate and 1-(2-isopropenylphenyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound.

Sources & evidence

ORD record
ord-55d69c84fa5a46abaf67022bab1e126d
Source dataset
uspto-grants-2000_02
Patent number
US06028195

Reaction notes

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