1-(3,5-Difluorophenyl)piperazine → 1-[(2-Methoxy-6-methyl-5-propylpyridin-3-yl)aminocarbonyl]-4-(3,5-difluorophenyl)piperazine

HRID 377827Notes

Reaction equation

HRID 377827 reaction equation
[CH3:1][O:2][C:3]1[C:8]([NH:9][C:10](=[O:18])OC2C=CC=CC=2)=[CH:7][C:6]([CH2:19][CH2:20][CH3:21])=[C:5]([CH3:22])[N:4]=1.[F:23][C:24]1[CH:25]=[C:26]([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH:27]=[C:28]([F:30])[CH:29]=1>>[CH3:1][O:2][C:3]1[C:8]([NH:9][C:10]([N:34]2[CH2:33][CH2:32][N:31]([C:26]3[CH:25]=[C:24]([F:23])[CH:29]=[C:28]([F:30])[CH:27]=3)[CH2:36][CH2:35]2)=[O:18])=[CH:7][C:6]([CH2:19][CH2:20][CH3:21])=[C:5]([CH3:22])[N:4]=1

Participants

3

Reactant 2

HCID 109872191-(3,5-Difluorophenyl)piperazineHCID 19357057Phenyl N-(2-methoxy-6-methyl-5-propylpyridin-3-yl)carbamate

Product 1

HCID 193571821-[(2-Methoxy-6-methyl-5-propylpyridin-3-yl)aminocarbonyl]-4-(3,5-difluorophenyl)piperazineYield 57%

Procedure

Phenyl N-(2-methoxy-6-methyl-5-propylpyridin-3-yl)carbamate and 1-(3,5-difluorophenyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound.

Sources & evidence

ORD record
ord-03549269e4984018b851c502b50671f7
Source dataset
uspto-grants-2000_02
Patent number
US06028195

Reaction notes

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