1-(2-Methoxyphenyl)piperazine → 1-[(2-Methoxy-6-methyl-5-propylpyridin-3-yl)aminocarbonyl]-4-(2-methoxyphenyl)piperazine

HRID 377828Notes

Reaction equation

HRID 377828 reaction equation
[CH3:1][O:2][C:3]1[C:8]([NH:9][C:10](=[O:18])OC2C=CC=CC=2)=[CH:7][C:6]([CH2:19][CH2:20][CH3:21])=[C:5]([CH3:22])[N:4]=1.[CH3:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[CH3:1][O:2][C:3]1[C:8]([NH:9][C:10]([N:34]2[CH2:33][CH2:32][N:31]([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[O:24][CH3:23])[CH2:36][CH2:35]2)=[O:18])=[CH:7][C:6]([CH2:19][CH2:20][CH3:21])=[C:5]([CH3:22])[N:4]=1

Participants

3

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 19357057Phenyl N-(2-methoxy-6-methyl-5-propylpyridin-3-yl)carbamate

Product 1

HCID 193570261-[(2-Methoxy-6-methyl-5-propylpyridin-3-yl)aminocarbonyl]-4-(2-methoxyphenyl)piperazineYield 71%

Procedure

Phenyl N-(2-methoxy-6-methyl-5-propylpyridin-3-yl)carbamate and 1-(2-methoxyphenyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound.

Sources & evidence

ORD record
ord-5b660d49092c4c8a85243497c03be74b
Source dataset
uspto-grants-2000_02
Patent number
US06028195

Reaction notes

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