1-(3-Hydroxyphenyl)piperazine → 1-[(2-Methoxy-5-methyl-6-propylpyridin-3-yl)aminocarbonyl]-4-(3-hydroxyphenyl)piperazine

HRID 377834Notes

Reaction equation

HRID 377834 reaction equation
[CH3:1][O:2][C:3]1[C:8]([NH:9][C:10](=[O:18])OC2C=CC=CC=2)=[CH:7][C:6]([CH3:19])=[C:5]([CH2:20][CH2:21][CH3:22])[N:4]=1.[OH:23][C:24]1[CH:25]=[C:26]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)[CH:27]=[CH:28][CH:29]=1>>[CH3:1][O:2][C:3]1[C:8]([NH:9][C:10]([N:33]2[CH2:32][CH2:31][N:30]([C:26]3[CH:27]=[CH:28][CH:29]=[C:24]([OH:23])[CH:25]=3)[CH2:35][CH2:34]2)=[O:18])=[CH:7][C:6]([CH3:19])=[C:5]([CH2:20][CH2:21][CH3:22])[N:4]=1

Participants

3

Reactant 2

HCID 27365971-(3-Hydroxyphenyl)piperazineHCID 19357120Phenyl N-(2-methoxy-5-methyl-6-propylpyridin-3-yl)carbamate

Product 1

HCID 193571021-[(2-Methoxy-5-methyl-6-propylpyridin-3-yl)aminocarbonyl]-4-(3-hydroxyphenyl)piperazineYield 52%

Procedure

Phenyl N-(2-methoxy-5-methyl-6-propylpyridin-3-yl)carbamate and 1-(3-hydroxyphenyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound.

Sources & evidence

ORD record
ord-8c929fc5117f4bcfb60cf92aebae7481
Source dataset
uspto-grants-2000_02
Patent number
US06028195

Reaction notes

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