1-(3-Hydroxyphenyl)piperazine → 1-[(5-Acetyl-2-methoxy-6-methylpyridin-3-yl)aminocarbonyl]-4-(3-hydroxyphenyl)piperazine

HRID 377860Notes

Reaction equation

HRID 377860 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([NH:13][C:14](=[O:22])OC2C=CC=CC=2)[C:7]([O:11][CH3:12])=[N:8][C:9]=1[CH3:10])(=[O:3])[CH3:2].[OH:23][C:24]1[CH:25]=[C:26]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)[CH:27]=[CH:28][CH:29]=1>>[C:1]([C:4]1[CH:5]=[C:6]([NH:13][C:14]([N:33]2[CH2:32][CH2:31][N:30]([C:26]3[CH:27]=[CH:28][CH:29]=[C:24]([OH:23])[CH:25]=3)[CH2:35][CH2:34]2)=[O:22])[C:7]([O:11][CH3:12])=[N:8][C:9]=1[CH3:10])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 27365971-(3-Hydroxyphenyl)piperazineHCID 19357047Phenyl N-(5-acetyl-2-methoxy-6-methylpyridin-3-yl)carbamate

Product 1

HCID 193569621-[(5-Acetyl-2-methoxy-6-methylpyridin-3-yl)aminocarbonyl]-4-(3-hydroxyphenyl)piperazineYield 76%

Procedure

Phenyl N-(5-acetyl-2-methoxy-6-methylpyridin-3-yl)carbamate and 1-(3-hydroxyphenyl)piperazine were reacted by the same way with the example 46 to obtain the titled compound.

Sources & evidence

ORD record
ord-f43afe96f1424e1ca6049e7def4c4826
Source dataset
uspto-grants-2000_02
Patent number
US06028195

Reaction notes

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