Phenyl N-(2-methoxyquinolin-3-yl)carbamate → 1-[(2-Methoxyquinolin-3-yl)aminocarbonyl]-4-(2-methoxy-5-methylphenyl)piperazine

HRID 377880Notes

Reaction equation

HRID 377880 reaction equation
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:22])OC2C=CC=CC=2)=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.[CH3:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][C:26]=1[N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:35]2[CH2:34][CH2:33][N:32]([C:26]3[CH:27]=[C:28]([CH3:31])[CH:29]=[CH:30][C:25]=3[O:24][CH3:23])[CH2:37][CH2:36]2)=[O:22])=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 19356985Phenyl N-(2-methoxyquinolin-3-yl)carbamateHCID 193571151-(2-Methoxy-5-methylphenyl)piperazine

Product 1

HCID 193571331-[(2-Methoxyquinolin-3-yl)aminocarbonyl]-4-(2-methoxy-5-methylphenyl)piperazineYield 76%

Procedure

Phenyl N-(2-methoxyquinolin-3-yl)carbamate and 1-(2-methoxy-5-methylphenyl)piperazine were reacted by the same way with the example 81 to obtain the titled compound.

Sources & evidence

ORD record
ord-df4b7a9b7f9448a8929a7e62254fdc60
Source dataset
uspto-grants-2000_02
Patent number
US06028195

Reaction notes

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