反应详情

To 3,4-dimethylphenol(19.3 g, 0.16 mol), methanol(150 ml) and KOH(9.65 g, 0.25 mol) were added and then refluxed for 2 hrs. Methyl iodide(36.5 g, 0.25 mol) was added thereto, refluxed for 3 hours and then followed by addition of water(150 ml). The resulting mixture was extracted with ethylacetate and purified by column chromatography to obtain the titled compound.

1. temperaturerefluxed for 2 hrs
2. temperaturerefluxed for 3 hours
3. extractionThe resulting mixture was extracted with ethylacetate
4. custompurified by column chromatography