HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperazine → 1-[(4,5-Dimethyl-2-methoxyphenyl)aminocarbonyl]-4-phenylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | Phenyl N-(4,5-dimethyl-2-methoxyphenyl)carbamate | HCID 19357180 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[(4,5-Dimethyl-2-methoxyphenyl)aminocarbonyl]-4-phenylpiperazine | HCID 19357111 | 85% |
Reaction Steps
Phenyl N-(4,5-dimethyl-2-methoxyphenyl)carbamate(5.422 g, 0.02 mol) and 1-phenylpiperazine(3.44 g, 0.02 mol) were dissolved in tetrahydrofuran(10 ml). After DBU(3.04 g, 0.02 mol) was added, the resulting solution was stirred at room temperature for 2 hrs, concentrated and purified by column chromatography to obtain the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06028195 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-81bca9f757c44da28d317960dc2fbdd9 |
| Source note | uspto-grants-2000_02 |