1-(3-Hydroxyphenyl)piperazine → 1-[(4,5-Dimethyl-2-methoxyphenyl)aminothiocarbonyl]-4-(3-hydroxyphenyl)piperazine

HRID 377927Notes

Reaction equation

HRID 377927 reaction equation
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([NH:9][C:10](=[S:18])OC2C=CC=CC=2)=[C:4]([O:19][CH3:20])[CH:3]=1.[OH:21][C:22]1[CH:23]=[C:24]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:25]=[CH:26][CH:27]=1>>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([NH:9][C:10]([N:31]2[CH2:30][CH2:29][N:28]([C:24]3[CH:25]=[CH:26][CH:27]=[C:22]([OH:21])[CH:23]=3)[CH2:33][CH2:32]2)=[S:18])=[C:4]([O:19][CH3:20])[CH:3]=1

Participants

3

Reactant 2

HCID 27365971-(3-Hydroxyphenyl)piperazineHCID 53857756Phenyl N-(4,5-dimethyl-2-methoxyphenyl)thiocarbamate

Product 1

HCID 539525011-[(4,5-Dimethyl-2-methoxyphenyl)aminothiocarbonyl]-4-(3-hydroxyphenyl)piperazineYield 77%

Procedure

Phenyl N-(4,5-dimethyl-2-methoxyphenyl)thiocarbamate and 1-(3-hydroxyphenyl)piperazine were reacted by the same way with the example 197 to obtain the titled compound.

Sources & evidence

ORD record
ord-d202baadfa02439bab74830250ad90c8
Source dataset
uspto-grants-2000_02
Patent number
US06028195

Reaction notes

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