Hydrochloric Acid → HCID 19357174, compound

Participants

Reaction Steps

Ethyl 2-({[4-(3,5-dimethoxyphenyl)piperazino]carbonyl}-2-methoxy-4,5-dimethylanilino)acetate(200 mg, 0.41 mmole) was dissolved in dioxane:distilled water(4:1, 15 ml), lithium hydroxide monohydrate(50.7 mg, 1.23 mmol) was added thereto, and then the resulting mixture was stirred at room temperature for 3 hours, acidified with 1N-hydrochloric acid, extracted with ethylacetate, filtered to dryness, concentrated under the reduced pressure to remove the used solvent, and purified by column chromatography(ethylacetate:hexane=1:2) to obtain the titled compound.

Provenance & Evidence