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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 377940Generated: October 25, 2026

1-(3,5-Difluorophenyl)piperazine → 1-[(2-Hydroxy-4,5-dimethylphenyl)aminocarbonyl]-4-(3,5-difluorophenyl)piperazine

https://huagongshe.com/reaction/377940

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(3,5-Difluorophenyl)piperazineHCID 10987219—
ReactantPhenyl N-(2-hydroxy-4,5-dimethylphenyl)carbamateHCID 19356987—
Product1-[(2-Hydroxy-4,5-dimethylphenyl)aminocarbonyl]-4-(3,5-difluorophenyl)piperazineHCID 1935713280%

Reaction Steps

Phenyl N-[2-hydroxy-4,5-dimethylphenyl)carbamate and 1-(3,5-difluorophenyl)piperazine were reacted by the same way with the example 228 to obtain the titled compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06028195
Source datasetuspto-grants-2000_02
ORD IDord-80e22095ebeb472d962ef393d367896b
Source noteuspto-grants-2000_02