1-(3,5-Dichlorophenyl)piperazine → 1-[(2-Hydroxy-4,5-dimethylphenyl)aminocarbonyl]-4-(3,5-dichlorophenyl)piperazine

HRID 377941Notes

Reaction equation

HRID 377941 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([CH3:9])=[CH:4][C:3]=1[NH:10][C:11](=[O:19])OC1C=CC=CC=1.[Cl:20][C:21]1[CH:22]=[C:23]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:24]=[C:25]([Cl:27])[CH:26]=1>>[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([CH3:9])=[CH:4][C:3]=1[NH:10][C:11]([N:31]1[CH2:30][CH2:29][N:28]([C:23]2[CH:22]=[C:21]([Cl:20])[CH:26]=[C:25]([Cl:27])[CH:24]=2)[CH2:33][CH2:32]1)=[O:19]

Participants

3

Reactant 2

HCID 27360671-(3,5-Dichlorophenyl)piperazineHCID 19356987Phenyl N-(2-hydroxy-4,5-dimethylphenyl)carbamate

Product 1

HCID 193570971-[(2-Hydroxy-4,5-dimethylphenyl)aminocarbonyl]-4-(3,5-dichlorophenyl)piperazineYield 77%

Procedure

Phenyl N-(2-hydroxy-4,5-dimethylphenyl)carbamate and 1-(3,5-dichlorophenyl)piperazine were reacted by the same way with the example 228 to obtain the titled compound.

Sources & evidence

ORD record
ord-630ab14807004dd684fdf76df8cb8dfd
Source dataset
uspto-grants-2000_02
Patent number
US06028195

Reaction notes

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