HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-4-(trifluoromethyl)benzene → (+)-Fluoxetine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-4-(trifluoromethyl)benzene | HCID 7394 | — |
| Reactant | (1R)-3-(methylamino)-1-phenylpropan-1-ol | HCID 7020931 | — |
| Product | (+)-Fluoxetine | HCID 1548970 | — |
Reaction Steps
A process according to claim 6 comprising the additional step, following all preceding steps, of reacting (R)-3-(methylamino)-1-phenylpropanol with a strong base followed by 4-chlorobenzotrifluoride to provide (R)-N-methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06028224 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-8153c2f105174ba99ee903e23c405933 |
| Source note | uspto-grants-2000_02 |