Paclitaxel → 10-Deacetyltaxol

Participants

Reaction Steps

where R represents C6H5 (taxol analogue A or xyloside A), or CH3C=CHCH3 (taxol analogue B or xyloside B) or C5H11 (taxol analogue C or xyloside C) in a polar solvent (b) reacting the resultant solution with periodate for 20-40 hours at 20-40° C. to cleave the diol system of the xyloside into dialdehyde, (c) treating the generated dialdehyde in a mixture of polar solvent-organic acid mixture with salts of amines at 0-40° C. for 12-18 hours and (d) isolating the 10-deacetyl taxol A,B,C by chromatography.

Provenance & Evidence