HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[(E)-2-(2,4-Difluorophenyl)ethenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → HCID 53251101, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[(E)-2-(2,4-Difluorophenyl)ethenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 16218154 | — |
| Reactant | 7-bromo-3,4,5,6-tetrahydro-1H-2,5-ethanoazepino[4,3-b]indole | HCID 67240163 | — |
| Product | HCID 53251101 | HCID 53251101 | — |
Reaction Steps
A suspension of the product of Example 1B (100 mg, 0.34 mmol) and trans-2-(2,4-difluorophenyl)vinylboronic acid pinacol ester (101 mg, 0.38 mmol; Aldrich) was processed as described in Example 4 to provide the title compound: 1H NMR (400 MHz, methanol-d4) δ ppm 1.98-2.19 (m, 4 H), 3.03-3.17 (m, 3 H), 3.21-3.28 (m, 2 H), 4.24 (s, 2 H), 6.93-7.05 (m, 3 H), 7.25 (d, J=7.6 Hz, 1 H), 7.30 (d, J=16.2 Hz, 1 H), 7.37 (d, J=7.3 Hz, 1 H), 7.63 (d, J=16.5 Hz, 1 H), 7.79-7.88 (m, 1 H); MS (DCI) m/z 351 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524703B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-0b0514e413b245cab2a6a1abe9a874ec |
| Source note | uspto-grants-2013_09 |