Methyl iodide → HCID 18630181, compound

HRID 377995Notes

Reaction equation

HRID 377995 reaction equation
[CH2:1]([N:3]([CH2:17][CH3:18])[C:4](=[O:16])[C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:6]=1[Si:12]([CH3:15])([CH3:14])[CH3:13])[CH3:2].[CH3:19]I>>[CH2:17]([N:3]([CH2:1][CH3:2])[C:4](=[O:16])[C:5]1[C:6]([Si:12]([CH3:15])([CH3:14])[CH3:13])=[CH:7][C:8]([CH3:11])=[CH:9][C:10]=1[CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 18630203HCID 18630203, compound

Product 1

HCID 18630181HCID 18630181, compound

Procedure

The title compound was prepared from the compound of Example 58 and MeI (4.0 eq) according to General Method A. Purification by HPLC with 3:17 ethyl acetate/hexanes gave 1.4 g of the title compound as a clear oil, an 83% yield.

Workup

  1. customPurification by HPLC with 3:17 ethyl acetate/hexanes

Sources & evidence

ORD record
ord-12987cbb61c147ed86b1142a38e28600
Source dataset
uspto-grants-2000_02
Patent number
US06028101

Reaction notes

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