Chlorotriethylsilane → n,n-Diethyl-2-chloro-6-(triethylsilyl)benzamide

HRID 377999Notes

Reaction equation

HRID 377999 reaction equation
[CH2:1]([N:3]([CH2:13][CH3:14])[C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:2].Cl[Si:16]([CH2:21][CH3:22])([CH2:19][CH3:20])[CH2:17][CH3:18]>>[CH2:13]([N:3]([CH2:1][CH3:2])[C:4](=[O:12])[C:5]1[C:10]([Si:16]([CH2:21][CH3:22])([CH2:19][CH3:20])[CH2:17][CH3:18])=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:14]

Participants

3

Reactant 2

HCID 13819ChlorotriethylsilaneHCID 825662-Chloro-N,N-diethylbenzamide

Product 1

HCID 18630182n,n-Diethyl-2-chloro-6-(triethylsilyl)benzamide

Procedure

The title compound was prepared according to General Method A from the compound of Example e and 1.4 eq chlorotriethylsilane. Purification by HPLC with 1:19 ethyl acetate/hexanes gave 6.0 g of the desired product as a clear oil, a 92% yield.

Workup

  1. customThe title compound was prepared
  2. customPurification by HPLC with 1:19 ethyl acetate/hexanes

Sources & evidence

ORD record
ord-cfd985a7c9ba4c6582c42e886937554c
Source dataset
uspto-grants-2000_02
Patent number
US06028101

Reaction notes

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