Cyclopropylamine → HCID 18630189, compound

HRID 378061Notes

Reaction equation

HRID 378061 reaction equation
[CH2:1]([NH:3][C:4](=[O:16])[C:5]1[C:10]([Si:11]([CH3:14])([CH3:13])[CH3:12])=[CH:9][CH:8]=[CH:7][C:6]=1[I:15])[CH3:2].[CH:17]1(N)CC1>>[CH:1]1([NH:3][C:4](=[O:16])[C:5]2[C:10]([Si:11]([CH3:14])([CH3:13])[CH3:12])=[CH:9][CH:8]=[CH:7][C:6]=2[I:15])[CH2:17][CH2:2]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 18630276HCID 18630276, compound

Product 1

HCID 18630189HCID 18630189, compoundYield 87%

Procedure

The acid chloride prepared in Example 207 was reacted with cyclopropylamine (3 eq) using General Method El to afford the title compound. Purification by recrystallization from hexanes gave 0.49 g of the title compound as white needles in 87% yield. m.p. 162-164° C.

Sources & evidence

ORD record
ord-81e6d205ba2e48f4a64debbbe43917c1
Source dataset
uspto-grants-2000_02
Patent number
US06028101

Reaction notes

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