Ethylamine → 4-bromo-N-ethylthiophene-3-carboxamide

HRID 378089Notes

Reaction equation

HRID 378089 reaction equation
[Br:1][C:2]1[C:3]([C:7]([OH:9])=O)=[CH:4][S:5][CH:6]=1.[CH2:10]([NH2:12])[CH3:11]>O>[CH2:10]([NH:12][C:7]([C:3]1[C:2]([Br:1])=[CH:6][S:5][CH:4]=1)=[O:9])[CH3:11]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 855464-Bromo-3-thenoic acid

Product 1

HCID 186301214-bromo-N-ethylthiophene-3-carboxamideYield 64.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N-Ethyl-4-bromo-3-thiophenecarboxamide was prepared from 4-bromo-3-thiophenecarboxylic acid (7 g, 34 mmol) and 70% ethylamine in water according to steps a and b of Example 248 in 64.5% yield.

Sources & evidence

ORD record
ord-303b24d060884bda9fcec99f393ee3f5
Source dataset
uspto-grants-2000_02
Patent number
US06028101

Reaction notes

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