(Pyridin-4-yl)boronic acid → 7-(pyridin-4-yl)-3,4,5,6-tetrahydro-1H-2,5-ethanoazepino[4,3-b]indole

Participants

Reaction Steps

The product of Example 1B (100 mg, 0.34 mmol) and pyridine-4-boronic acid (52 mg, 0.38 mmol; Aldrich) were processed as described in Example 4 to provide the title compound: 1H NMR (400 MHz, methanol-d4) δ ppm 2.06-2.17 (m, 4 H), 3.06-3.18 (m, 3 H), 3.23-3.29 (m, 2 H), 4.30 (s, 2 H), 7.13 (t, J=7.6 Hz, 1 H), 7.17-7.20 (m, 1 H), 7.41 (dd, J=7.6, 1.2 Hz, 1 H), 7.70-7.74 (m, 2 H), 8.58-8.64 (m, 2 H); MS (APCI) m/z 290 (M+H)+.

Provenance & Evidence