反应详情

A suspension of the product of Step A (2.5 g) in methanol (100 ml) was treated with 4N HCl/dioxane (10 ml). The resulting solution was stirred overnight. The excess solvent was removed under reduced pressure and the semi solid was purified by HPLC (RP--CH3CN/H2O). The solid was dissolved in CH3CN/H2O, treated with 20% aqueous HCl (5 ml) and lyophilized to give methyl β-aminonaphthalene-2-propanoate hydrochloride (1.1 g). MS and 1H-NMR were consistent with the structure.

1. customThe excess solvent was removed under reduced pressure
2. customthe semi solid was purified by HPLC (RP--CH3CN/H2O)
3. dissolutionThe solid was dissolved in CH3CN/H2O
4. additiontreated with 20% aqueous HCl (5 ml)