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2-Thiophenecarboxaldehyde → Methyl 3-amino-3-(2-thienyl)propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Thiophenecarboxaldehyde | HCID 7364 | — |
| 反応物 | 3-Amino-3-(thiophen-2-yl)propanoic acid | HCID 249306 | — |
| 反応物 | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| 反応物 | Acetonitrile ether | HCID 21885917 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 3-amino-3-(2-thienyl)propanoate | HCID 2764295 | — |
反応手順
A solution of 3-amino-3-(2-thienyl)propanoic acid (0.5 g) [prepared substituting a molar equivalent amount of 2-thiophene-carboxaldehyde in Example 57, Step A] in methanol (50 ml) was treated with 4N HCl/dioxane (10 ml). After 6 hours the excess solvent was removed under reduced pressure to give a waxy solid. Treatment with Et2O/CH3CN produced methyl β-aminothiophene-2-propanoate (370 mg) as a white powder. MS and 1H-NMR were consistent with the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06028223 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-2d23fc5e8f0b4601948e7527f629a05a |
| 出典メモ | uspto-grants-2000_02 |