1,4-Dioxane hydrochloride → Methyl 3-amino-5-[(4-methylphenyl)thio]pentanoate

Participants

Reaction Steps

A solution of 3-amino-5-[(4-methylphenyl)thio]pentanoic acid (1.0 g) [prepared according to U.S. Pat. No. 5,409,939] in methanol (50 ml) was treated with 4N HCl/dioxane (10 ml). The reaction was stirred overnight at room temperature. The excess solvent was removed under reduced pressure. Methyl 3-amino-5-[(4-methylphenyl)thio]pentanoate (1.1 g) as a white solid was obtained. MS and 1H-NMR were consistent with the desired product.

Provenance & Evidence