Lithium Hydroxide → HCID 178514382, compound

Participants

Reaction Conditions

Reaction Steps

The compound of Example 96 (500 mg) was dissolved in water/acetonitrile (1:1) followed by the addition of lithium hydroxide (200 mg). The reaction mixture was stirred at 25° C., and monitored by HPLC. After complete hydrolysis (1-2 hours) triflouroacetic acid was added until pH=2. The product was purified by reverse phase chromatography (water/acetonitrile) to result in 375 mg of a white solid. MS and 1H-NMR were consistent with the proposed structure.

Provenance & Evidence