Lithium Hydroxide → HCID 178424950, compound

Participants

Reaction Steps

To the product from Example 180 (710 mg, 0.0013 mole) in H2O (10 mL) and CH3CN (10 mL) was added LiOH (215 mg, 0.005 mole). The reaction mixture was stirred at room temperature for 2.5 hours. The pH was lowered to ~3 with TFA and the product was isolated by RPHPLC to yield the title compound (600 mg after lyophilization) as a white solid.

Provenance & Evidence