Lithium Hydroxide → HCID 178514387, compound

Participants

Reaction Steps

To the product from Example 184 (1.0 mg, 0.00165 mole) in H2O (15 mL) and CH3CN (10 mL) was added LiOH (210 mg, 0.005 mole). The reaction mixture was stirred at room temperature for 1.5 hours. The pH was lowered to ~2.5 with TFA and the product was isolated by RPHPLC to yield the title compound (460 mg after lyophilization) as a white solid.

Provenance & Evidence