Lithium Hydroxide → HCID 178514386, compound

Participants

Reaction Steps

To the product from Example 186 (1.3 mg, 0.0023 mole) in H2O (15 mL) and CH3CN (15 mL) was added LiOH (290 mg, 0.0069 mole). The reaction mixture was stirred at room temperature for 1 hour. The pH was lowered to ~2.5 with TFA and the product was isolated by RPHPLC to yield the title compound (1.1 g after lyophilization) as a white solid.

Provenance & Evidence