Lithium Hydroxide → HCID 178424951, compound

Participants

Reaction Steps

To the product from Example 192 (730 mg, 0.0013 mole) in H2O (10 mL) and CH3CN (10 mL) was added LiOH (221 mg, 0.005 mole). The reaction mixture was stirred at room temperature for 1 hour. The pH was lowered to ~2.5 with TFA and the product was isolated by RPHPLC to yield the title compound (570 mg after lyophilization) as a white solid.

Provenance & Evidence