Lithium Hydroxide → HCID 178493449, compound

Participants

Reaction Steps

To the product from Example 194 (800 mg, 0.00014 mole) in H2O (20 mL) and CH3CN (8 mL) was added LiOH (230 mg, 0.0055 mole). The reaction mixture was stirred at room temperature for 1.5 hours. The pH was lowered to ~3 with TFA and the product was isolated by RPHPLC to yield the title compound (670 mg after lyophilization) as a white solid.

Provenance & Evidence