Lithium Hydroxide → HCID 131721704, compound

Participants

Reaction Steps

To the product from Example 202 (1.27 g, 0.002 mole) in H2O (15 mL) and CH3CN (15 mL) was added LiOH (345 mg, 0.0082 mole). The reaction mixture was stirred at room temperature for 1.5 hours. The pH was lowered to 2.7 with TFA and the product was isolated by RPHPLC to yield the title compound (80 mg after lyophilization) as a white solid. MS and NMR were consistent with the desired structure.

Provenance & Evidence