Hydrochloric Acid → HCID 54092064, compound

Participants

Reaction Steps

The product from Step A was taken up in absolute EtOH, dry HCl gas was added to saturation, and the mixture refluxed overnight. Volatiles were removed and the resulting semi-solid partitioned between ethyl acetate and water. The aqueous layer was made basic by addition of 2.5N NaOH and extracted with EtOAc (2×200 mL). The organic layer was dried (anhydrous NaSO4) and dry HCl gas added until precipitation ceased. Volatiles were removed until a semisolid residue remained. This was triturated with diethyl ether to obtain a solid that was collected by filtration. NMR and MS were consistent with the proposed structure.

Provenance & Evidence