Hydrochloric Acid → HCID 54110933, compound

Participants

Reaction Steps

A mixture of methyl 3-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-3-methyl-2,3-dihydrobenzofuran-5-yl]acrylate (330 mg, 0.79 mmol), a 2N methanolic sodium hydroxide solution (4 ml, 7.9 mmol) in THF (3 ml) is heated for 5 hours at 60° C. The mixture is acidified to pH 1 with a concentrated hydrochloric acid solution, extracted with ethyl acetate and washed with water. After drying the organic phase is concentrated in vacuo at 40° C. in a rotary evaporator, the product is purified by flash chromatography on a silica column.

Provenance & Evidence